TUGAIN Solution 10
Minoxidil ............................... 10% w/v
Also contains:
Absolute alcohol ................. 40% v/v
Dosage Form
Solution
Pharmacology
Pharmacodynamics
Minoxidil stimulates hair growth in persons with early and moderate stages of androgenic alopecia. It is not intended for frontal baldness or a receding hairline.
The mechanism by which minoxidil stimulates hair growth is not established, but possible mechanisms of action of minoxidil may include the following:
K+ATP-mediated stimulation of hair follicular cells by one of its sulphated active metabolites.
Stimulation and prolongation of the anagen phase of hair and increase in the follicular size, thereby preventing premature entry into the telogen phase.
Improvement in local microcirculation through its vasodilatory effect. Minoxidil stimulates VEGF (vascular endothelial growth factor) which is responsible for increased capillary fenestration, indicative of high metabolic activity, observed in anagen phase.
Increasing  diameter of the hair shaft
Stimulating anagen recovery from the telogen phase.
All people may not be responsive to topical minoxidil treatment. The amount of hair regrowth differs from person to person. Although data suggest that those users who have been balding for a shorter period or who have a smaller area of baldness on the vertex are more likely to respond to topical minoxidil, individual responses cannot be predicted. It is unlikely anyone will be able to grow back all of his or her hair.